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Professor of Mechanical Engineering

Adjunct Professor of Pediatrics

PhD, University of Toronto




Contact Information


Honors and Awards

  • Faulty Research Award, 2016
  • NSF CAREER Award, 2013


Research Interests

  • Colloid and surface science
  • Surface thermodynamics
  • Nano-bio interaction
  • Lipid-protein interactions
  • Lung surfactant
  • Tear film
  • Particle technology
  • Surface tension and contact angle measurement
  • Droplet and bubble
  • Interfacial rheology


Selected Publications

  1. Neumann AW, David R, Zuo Y (eds) Applied Surface Thermodynamics, 2nd edn, CRC Press, Boca Raton, FL, 2010.
  2. Xu L, Yang Y, Zuo YY*, Atomic force microscopy imaging of adsorbed pulmonary surfactant films, Biophys. J. (2020) in press.
  3. Li G, Robles Del Hierro G, Di JZ, Zuo YY*, Compound drop shape analysis with the Neumann number, Langmuir (2020) DOI: 10.1021/acs.langmuir.0c01216.
  4. Yang J, Michaud J, Jansen S, Schenk HJ*, Zuo YY*, Dynamic surface tension of xylem sap lipids. Tree Physiol. 40 (2020) 433-444.
  5. Cao Z, Tsai SN, Zuo YY*, An optical method for quantitatively determining the surface free energy of micro- and nanoparticles. Anal. Chem. 91 (2019) 12819-12826. (Front Cover)
  6. Bai X, Xu L, Tang JY, Zuo YY*, Hu G*, Adsorption of phospholipids at the air-water surface. Biophys. J. 117 (2019) 1224-1233.
  7. Tian F, Lin X*, Valle RP, Zuo YY*, Gu N*, Poly(amidoamine) dendrimer as a respiratory nanocarrier: Insights from experiments and molecular dynamics simulations, Langmuir 35 (2019) 5364-5371. (Supplementary Journal Cover)
  8. Yang J, Yu K, Tsuji T, Jha R, Zuo YY, Determining the surface dilational rheology of surfactant and protein films with a droplet waveform generator. J. Colloid Interface Sci. 537 (2019) 547–553.
  9. Yang Y, Xu L, Dekkers S, Zhang LG, Cassee FR, Zuo YY, Aggregation state of metal-based nanomaterials at the pulmonary surfactant film determines biophysical inhibition. Environ. Sci. Technol. 52 (2018) 8920-8929.
  10. Xu L, Zuo YY, Reversible phase transitions in the phospholipid monolayer. Langmuir 34 (2018) 8694-8700.
  11. Yu K, Yang J, Zuo YY, Droplet oscillation as an arbitrary waveform generator. Langmuir 34 (2018) 7042-7047.
  12. Xu L, Bosiljevac G, Yu K, Zuo YY, Melting of the dipalmitoylphosphatidylcholine monolayer. Langmuir 34 (2018) 4688–4694.
  13. Yang Y, Wu Y, Ren Q, Zhang LG, Liu S, Zuo YY, Biophysical assessment of pulmonary surfactant predicts the lung toxicity of nanomaterials. Small Methods 2 (2018) 1700367.
  14. Chen Y, Yang Y, Xu B, Wang S, Li B, Ma J, Gao J, Zuo YY, Liu S, Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis. J. Environ. Sci. 62 (2017) 100-114.
  15. Yang J, Yu K, and Zuo YY, Accuracy of axisymmetric drop shape analysis in determining surface and interfacial tensions, Langmuir 33 (2017) 8914-8923.
  16. Hu Q, Bai X, Hu G, and Zuo YY, Unveiling the molecular structure of pulmonary surfactant corona on nanoparticles, ACS Nano 11 (2017) 6832-6842.
  17. Milos S, Khazaee R, McCaig LA, Nygard K, Gardiner RB, Zuo YY, Yamashita C, Veldhuizen R, Impact of ventilation induced lung injury on the structure and function of lamellar bodies. Am. J. Physiol. Lung Cell Mol. Physiol. 313 (2017) L524-L533.
  18. Schenk HJ, Espino S, Romo DM, Nima N, Do AYT, Michaud JM, Papahadjopoulos-Sternberg B, Yang J, Zuo YY, Steppe K, Jansen S, Xylem surfactants introduce a new element to the cohesion-tension theory, Plant Physiol. 173 (2017) 1177-1196.
  19. Zuo YY, Chen R, Wang X, Yang J, Policova Z, Neumann AW, Phase transitions in dipalmitoylphosphatidylcholine monolayers, Langmuir 32 (2016) 8501-8506.
  20. Yu K, Yang J, and Zuo YY, Automated droplet manipulation using closed-loop axisymmetric drop shape analysis, Langmuir 32 (2016) 4820-4826.
  21. Hu Q, Jiao B, Shi X, Valle RP, Zuo YY, Hu G, Effects of graphene oxide nanosheets on ultrastructure and biophysical properties of pulmonary surfactant film. Nanoscale 7 (2015) 18025-18029.
  22. Valle RP, Wu T, Zuo YY, Biophysical influence of airborne carbon nanomaterials on nature pulmonary surfactant. ACS Nano 9 (2015) 5413-5421.
  23. Zhang X, Zhang Q, Yan T, Jiang Z, Zhang X, Zuo YY, Quantitatively predicting bacterial adhesion using surface free energy determined with a spectrophotometric method. Environ. Sci. Technol. 49 (2015) 6164-6171.
  24. Banaschewski BJH, Veldhuizen EJA, Keating E, Haagsman H, Zuo YY, Yamashita CM, Veldhuizen RAW, Surfactant supplemented with an antimicrobial peptide for the treatment of bacterial pneumonia: antimicrobial and biophysical properties. Antimicrob. Agents Chemother. 59 (2015) 3075-3083.
  25. Zhang X, Zhang Q, Yan T, Jiang Z, Zhang X, Zuo YY, Surface free energy activated high-throughput cell sorting, Anal. Chem. 86 (2014) 9350-9355.
  26. Zhang X, Jiang Z, Li M, Zhang X, Wang G, Chou A, Chen L, Yan H, Zuo YY, Rapid spectrophotometric method for determining surface free energy of microalgal cells, Anal. Chem. 86 (2014) 8751-8756.
  27. Valle RP, Huang CL, Loo JSC, Zuo YY, Increasing hydrophobicity of nanoparticles intensifies lung surfactant film inhibition and particle retention, ACS Sustainable Chem. & Eng. 2 (2014) 1574-1580.
  28. Goetzman ES, Alcorn JF, Bharathi SS, Uppala R, McHugh KJ, Kossmider B, Chen R, Zuo YY, McKinney RW, Skilling H, Suhrie KR, Karunanidhi A, Otsubo C, Ellis B, Mallampalli RK, ockley J, Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction, J. Biol. Chem. 289 (2014) 10668-10679.
  29. Hu G, Jiao B, Shi X, Valle RP, Fan Q, and Zuo YY, Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona. ACS Nano 7 (2013) 10525-10533.
  30. Zhang H, Wang YE, Neal CR, and Zuo YY, Differential effects of cholesterol and budesonide on biophysical properties of clinical surfactant. Pediatr. Res. 71 (2012) 316-323.
  31. Wang YE, Zhang H, Fan Q, Neal CR, and Zuo YY, Biophysical interaction between corticosteroids and natural surfactant preparation: implications to pulmonary drug delivery using surfactant as a carrier, Soft Matter 8 (2012) 504-511.
  32. Fan Q, Wang YE, Zhao X, Loo JSC, and Zuo YY, Adverse biophysical effects of hydroxyapatite nanoparticles on natural pulmonary surfactant, ACS Nano 5 (2011) 6410-6416.
  33. Zhang H, Wang YE, Fan Q, and Zuo YY, On the low surface tension of lung surfactant, Langmuir 27 (2011) 8351-8358.
  34. Zhang H, Fan Q, Wang YE, Neal CN, and Zuo YY, Comparative Study of clinical pulmonary surfactants using atomic force microscopy, Biochim. Biophys. Acta 1808 (2011) 1832-1842.
  35. Zuo YY, Veldhuizen RAW, Neumann AW, Petersen NO, Possmayer F, Current perspectives in pulmonary surfactant – inhibition, enhancement and evaluation, Biochim. Biophys. Acta 1778 (2008) 1947-1977.

Click here for Dr. Zuo’s publications on PubMed.


Courses Offered

  • ME311 Thermodynamics
  • ME322 Mechanics of Fluids and Lab
  • ME422 Heat Transfer and Lab
  • ME480 Thermofluid Measurements and Design
  • ME491 How to Do Research
  • ME611 Advanced Thermodynamics
  • ME612 Statistical Thermodynamics
  • ME650 Surface Phenomena
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